[麻风病患者皮肤中S100阳性树突状细胞定量的图像分析]

[Image analysis to quantify S100-positive dendritic cells in leprosy-affected skin].

作者信息

Camargo Luz H, Caldas María Leonor, Neira Marcela, Sarmiento Ladys

机构信息

Unidad de Microscopía y Análisis de Imágenes, Instituto Nacional de Salud, Bogotá, D.C., Colombia.

出版信息

Biomedica. 2003 Jun;23(2):131-3.

PMID:12872551

Abstract

A morphometric analysis of skin dendritic cells was done on biopsies of patients with different forms of leprosy. An anti S100 antibody was used to determine dendritic cell quantity and extension. Patients with a better immune response to the bacillus showed a greater number of dendritic cells in the cases of dimorphic tuberculoid leprosy and tuberculoid leprosy. This result contrasted with that from patients with dimorphic lepromatous leprosy and lepromatous leprosy.

摘要

对不同类型麻风病患者的活检组织进行了皮肤树突状细胞的形态计量分析。使用抗S100抗体来确定树突状细胞的数量和分布范围。在双相结核样型麻风病和结核样型麻风病病例中，对杆菌免疫反应较好的患者显示出更多的树突状细胞。这一结果与双相瘤型麻风病和瘤型麻风病患者的结果形成对比。