García Herbert, Salguero Gustavo Andrés, Moreno Jeffer, Arteaga Clara, Giraldo Alejandro
Instituto de Genética, Universidad Nacional de Colombia, Bogotá, D.C., Colombia.
Biomedica. 2003 Jun;23(2):161-72.
At the Instituto Materno Infantil (IMI) in Bogotá (Colombia), 5,686 births (5,597 live births and 89 stillbirths) were analyzed during two periods: from October, 1997, to April, 1998, and from July to November, 2000 (12 months). Congenital anomalies were detected in 4.4% of live newborn babies and in 7.8% of stillbirths. Major anomalies corresponded to 69% and mild anomalies to 31% (3% and 1.4% of all live births, respectively). The newborn babies with major anomalies, in comparison to the normal controls, had higher mortality at hospital discharge (p = 0.0001), lower average birth weight (p = 0.003), and family history of congenital anomalies (p = 0.0001). The only significant association for mild anomalies was with family history of congenital anomalies (p = 0.0001). The frequency of congenital anomalies was similar to that in other studies, although certain kinds of anomalies showed noticeable frequency differences. This may be a consequence of differences in record keeping or in detection methods.
在哥伦比亚波哥大的妇幼研究所(IMI),对两个时间段内的5686例分娩(5597例活产和89例死产)进行了分析:1997年10月至1998年4月,以及2000年7月至11月(12个月)。在4.4%的活产新生儿和7.8%的死产中检测到先天性异常。主要异常占69%,轻度异常占31%(分别占所有活产的3%和1.4%)。与正常对照组相比,患有主要异常的新生儿在出院时死亡率更高(p = 0.0001),平均出生体重更低(p = 0.003),且有先天性异常家族史(p = 0.0001)。轻度异常唯一显著的关联是与先天性异常家族史(p = 0.0001)。先天性异常的频率与其他研究相似,尽管某些类型的异常显示出明显的频率差异。这可能是记录保存或检测方法不同的结果。