Structure--activity relationships of azasugar-based MMP/ADAM inhibitors.
作者信息
Moriyama Hideki, Tsukida Takahiro, Inoue Yoshimasa, Kondo Hirosato, Yoshino Kohichiro, Nishimura Shin-ichiro
机构信息
Japan Bioindustry Association, Hokkaido Collaboration Center, N-21, W-12, Kita-Ku, Sapporo 001-0021 Japan.
出版信息
Bioorg Med Chem Lett. 2003 Aug 18;13(16):2737-40. doi: 10.1016/s0960-894x(03)00530-4.
Abstract
In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.
摘要
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