Gargaglioni Luciane H, Coimbra Norberto C, Branco Luiz G S
Department of Morphology, Stomatology and Physiology, Dental School of Ribeirao Preto, University of Sao Paulo, SP, Ribeirao Preto, Brazil.
Neurosci Lett. 2003 Aug 21;347(2):121-5. doi: 10.1016/s0304-3940(03)00671-2.
The nucleus raphe magnus (NRM) is one of the brainstem cell groups involved in physiological responses to hypoxia. Thus, we tested the hypothesis that the NRM modulates hypoxia-induced hyperventilation and anapyrexia. To this end, we assessed the participation of NRM in the respiratory and thermoregulatory responses to hypoxia using ibotenic acid lesions produced in the NRM of rats. Our results demonstrated that, under resting breathing, NRM plays no role in ventilation or body temperature. Hypoxia caused hyperventilation and anapyrexia in all groups. NMR lesions elicited an increased ventilatory response to hypoxia due to a higher tidal volume (V(T)) but did not affect hypoxia-induced anapyrexia. Therefore, we conclude that NRM exerts an inhibitory modulation of breathing during hypoxia, acting on V(T), but plays no role in the hypoxia-induced anapyrexia.
中缝大核（NRM）是参与对缺氧的生理反应的脑干细胞群之一。因此，我们检验了中缝大核调节缺氧诱导的通气过度和低体温的假说。为此，我们使用在大鼠中缝大核产生的鹅膏蕈氨酸损伤来评估中缝大核在对缺氧的呼吸和体温调节反应中的参与情况。我们的结果表明，在静息呼吸状态下，中缝大核对通气或体温没有影响。缺氧在所有组中均引起通气过度和低体温。中缝大核损伤由于潮气量（V(T)）增加而引起对缺氧的通气反应增强，但不影响缺氧诱导的低体温。因此，我们得出结论，中缝大核在缺氧期间对呼吸发挥抑制性调节作用，作用于潮气量，但在缺氧诱导的低体温中不起作用。
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