Ekoé J M, Ghadirian P, Simard A, Baillargeon J, Perret C
Unité de Recherche en Epidémiologie, Centre de Recherche, Hôtel-Dieu de Montréal, Québec, Canada.
Rev Epidemiol Sante Publique. 1992;40(6):447-53.
In a population-based case-control study of dietary risk factors in French Canadians in Montreal, a total of 179 cases and 239 controls were interviewed between 1984 and 1988. It was found that the frequency of diabetes was almost three times higher in cases of pancreatic cancer (16%) than in the controls (6%), with an Odds Ratio (OR) of 2.52 and a Confidence Interval (CI) of 1.04-6.11. Fifty per cent of the pancreatic cancer cases had this disease before the cancer was diagnosed, compared with 71% of the controls at the time of the study. Those aged 50 years and over accounted for 75% of the cases and 71% of the controls (diabetic subjects); 68% of the cases were treated with a combination of diet and oral hypoglycemic agents compared with 86% of the controls. Insulin was used by 32% of the cases and 14% of the controls. These results suggest that diabetes may play a major role in the etiopathogenesis of pancreatic cancer in this urban population. A lot of controversy remains about the precise role of diabetes, and further studies are needed for a better assessment and understanding of the mechanisms of this association.
在一项针对蒙特利尔法裔加拿大人饮食风险因素的基于人群的病例对照研究中，1984年至1988年间共对179例病例和239名对照进行了访谈。结果发现，胰腺癌病例中糖尿病的发生率（16%）几乎是对照组（6%）的三倍，优势比（OR）为2.52，置信区间（CI）为1.04 - 6.11。50%的胰腺癌病例在癌症确诊前就患有糖尿病，而在研究时对照组的这一比例为71%。50岁及以上的人群占病例的75%，占对照组（糖尿病患者）的71%；68%的病例采用饮食和口服降糖药联合治疗，而对照组的这一比例为86%。32%的病例使用胰岛素，对照组为14%。这些结果表明，在这个城市人群中，糖尿病可能在胰腺癌的发病机制中起主要作用。关于糖尿病的确切作用仍存在很多争议，需要进一步研究以更好地评估和理解这种关联的机制。
