[慢性乙型或丙型病毒性肝炎患儿的抗凝血酶III、蛋白C和蛋白S]

[Antithrombin III, protein C and protein S in children with chronic viral hepatitis B or C].

作者信息

Adamska Inga, Szaflarska-Szczepanik Anna, Chrobot Andrzej, Kulwas Arleta, Czerwionka-Szaflarska Mieczysława

机构信息

Katedra i Klinika Pediatrii, Alergologii i Gastroenterologii, Akademia Medyczna, ul. M. Skłodowskiej-Curie 9, 85-094 Bydgoszcz, Poland.

出版信息

Med Wieku Rozwoj. 2003 Apr-Jun;7(2):289-97.

PMID:12878800

Abstract

Abnormalities of blood coagulation are a major part of acute and chronic viral hepatitis. In this study antithrombin III, protein C and protein S were determined in 100 children with chronic hepatitis B or C infection (range age 3-17) according to degree of hepatic histological activity and fibrosis. There was no statistically significant correlation between levels of examined parameters in children with chronic viral hepatitis compared with those in control group and between the degree of hepatic histological activity and fibrosis and coagulation parameters.

摘要

凝血异常是急慢性病毒性肝炎的一个主要部分。在本研究中，根据肝脏组织学活性和纤维化程度，对100例慢性乙型或丙型肝炎感染儿童（年龄范围3至17岁）测定了抗凝血酶III、蛋白C和蛋白S。与对照组相比，慢性病毒性肝炎儿童的检测参数水平之间，以及肝脏组织学活性和纤维化程度与凝血参数之间，均无统计学上的显著相关性。