Willinek Winfried A, Gieseke Jürgen, von Falkenhausen Marcus, Neuen Barbara, Schild Hans H, Kuhl Christiane K
Department of Radiology, University of Bonn, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany.
Radiology. 2003 Sep;228(3):669-75. doi: 10.1148/radiol.2283020243. Epub 2003 Jul 24.
To evaluate sensitivity encoding (SENSE) technique in a clinical setting for magnetic resonance (MR) imaging in patients who are suspected of having infarction.
This intraindividual comparative study included 62 patients suspected of having cerebral ischemia. Patients underwent T2-weighted fluid-attenuated inversion-recovery (FLAIR) (n = 62), T2-weighted turbo spin-echo (TSE) (n = 48), and single-shot echo-planar diffusion-weighted imaging (n = 27) with standard sequential and SENSE MR acquisitions with a 1.5-T magnet and phased-array coil. With SENSE, acquisition time was reduced from 1 minute 12 seconds to 35 seconds for FLAIR and from 1 minute 18 seconds to 39 seconds for T2-weighted TSE imaging. For diffusion-weighted imaging, echo train length was shortened (78 vs 71 msec) to reduce susceptibility effects while acquisition time was maintained. Two radiologists scored quality of standard and SENSE images with a five-point scale and assessed presence of artifacts (motion, susceptibility) and lesion conspicuity. To assess statistical significance, Wilcoxon signed rank and chi2 tests were used.
Statistical analysis revealed no significant difference in terms of image quality and presence of artifacts between standard and SENSE T2-weighted TSE (image quality, P =.724; presence of artifacts, P =.378) and FLAIR (image quality, P =.127; presence of artifacts, P =.275) images. Image quality at SENSE diffusion-weighted imaging was scored significantly higher compared with that at standard diffusion-weighted imaging (P =.002). Susceptibility artifacts were significantly reduced at SENSE diffusion-weighted imaging when compared with those at standard diffusion-weighted imaging (P <.001). Conspicuity of 84 lesions was rated equivalent with both standard and SENSE protocols.
SENSE allowed acquisition of T2-weighted TSE and FLAIR images with image quality and lesion conspicuity that did not differ from those of standard acquisition techniques but in only half the acquisition time. Use of SENSE with diffusion-weighted imaging significantly reduces susceptibility artifacts while lesion conspicuity is maintained.
评估敏感性编码（SENSE）技术在临床环境中对疑似梗死患者进行磁共振（MR）成像的效果。
这项个体内比较研究纳入了62例疑似脑缺血的患者。患者接受了T2加权液体衰减反转恢复（FLAIR）序列（n = 62）、T2加权快速自旋回波（TSE）序列（n = 48）以及单次激发回波平面扩散加权成像（n = 27），采用1.5-T磁共振仪和相控阵线圈进行标准序列和SENSE MR采集。使用SENSE技术时，FLAIR序列的采集时间从1分12秒缩短至35秒，T2加权TSE成像的采集时间从1分18秒缩短至39秒。对于扩散加权成像，回波链长度缩短（78对71毫秒）以减少磁化率效应，同时保持采集时间不变。两名放射科医生采用五点量表对标准图像和SENSE图像的质量进行评分，并评估伪影（运动、磁化率）的存在情况和病变的清晰度。为评估统计学意义，采用了Wilcoxon符号秩检验和卡方检验。
统计分析显示，标准T2加权TSE图像与SENSE T2加权TSE图像（图像质量，P = 0.724；伪影存在情况，P = 0.378）以及FLAIR图像（图像质量，P = 0.127；伪影存在情况，P = 0.275）在图像质量和伪影存在方面均无显著差异。SENSE扩散加权成像的图像质量评分显著高于标准扩散加权成像（P = 0.002）。与标准扩散加权成像相比，SENSE扩散加权成像的磁化率伪影显著减少（P < 0.001）。84个病变的清晰度在标准协议和SENSE协议下的评分相当。
SENSE技术能够采集T2加权TSE和FLAIR图像，其图像质量和病变清晰度与标准采集技术无异，但采集时间仅为标准技术的一半。在扩散加权成像中使用SENSE技术可显著减少磁化率伪影，同时保持病变清晰度。
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