Enhanced production of recombinant B-domain deleted factor VIII from Chinese hamster ovary cells by propionic and butyric acids.
作者信息
Chun Bok-Hwan, Park Song-Yong, Chung Namhyun, Bang Won-Gi
机构信息
Department of Agricultural Chemistry, College of Life and Environmental Sciences, Korea University, 5 Ga Anamdong, Sungbook-gu, Seoul 136-075, Korea.
出版信息
Biotechnol Lett. 2003 Feb;25(4):315-9. doi: 10.1023/a:1022301528118.
PMID:12882544
Abstract
Sodium propionate, as well as sodium butyrate, enhanced the production of recombinant B-domain-deleted, factor VIII (rFVIIIdB) by Chinese hamster ovary cells growing in a spinner-flask with a protein-free medium by more than six-fold. The two acids, however, had different cytotoxicities.
摘要
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