环糊精辅助毛细管电泳法测定环状硝胺炸药黑索金、奥克托今和CL-20——与高效液相色谱法的比较

Cyclodextrin-assisted capillary electrophoresis for determination of the cyclic nitramine explosives RDX, HMX and CL-20 comparison with high-performance liquid chromatography.

作者信息

Groom Carl A, Halasz Annamaria, Paquet Louise, D'Cruz Philomena, Hawari Jalal

机构信息

Biotechnology Research Institute, National Research Council Canada, 6100 Royalmount Avenue, Montreal, Quebec H4P 2R2, Canada.

出版信息

J Chromatogr A. 2003 May 30;999(1-2):17-22. doi: 10.1016/s0021-9673(03)00389-3.

DOI:10.1016/s0021-9673(03)00389-3

PMID:12885047

Abstract

A sulfobutyl ether-beta-cyclodextrin-assisted electrokinetic chromatographic method was developed to rapidly resolve and detect the cyclic nitramine explosives 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaaza-isowurtzitane (CL-20), octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and their related degradation intermediates in environmental samples. Development of the electrophoretic method required the measurement of the aqueous solubility of CL-20 which was determined to be 3.59 +/- 0.74 mg/l at 25 degrees C (95% confidence interval, n=3). The performance of the method was then compared to results obtained from existing high-performance liquid chromatography methods including US Environmental Protection Agency method 8330.

摘要

开发了一种磺丁基醚-β-环糊精辅助电动色谱法，用于快速分离和检测环境样品中的环状硝胺炸药2,4,6,8,10,12-六硝基-2,4,6,8,10,12-六氮杂异伍兹烷（CL-20）、八氢-1,3,5,7-四硝基-1,3,5,7-四氮杂环辛烷（HMX）和六氢-1,3,5-三硝基-1,3,5-三嗪（RDX）及其相关降解中间体。电泳方法的开发需要测定CL-20的水溶性，在25℃下其水溶性测定为3.59±0.74mg/l（95%置信区间，n = 3）。然后将该方法的性能与现有高效液相色谱法（包括美国环境保护局方法8330）获得的结果进行比较。