[Morphological changes in the structure of liver cell nuclei in rats with PP anitaminosis following injection of nicotinic acid].

The injection of the surplus quantities of nicotinic acid (150 mg/kg of body weight) to PP-deficient rats causes morphological changes in the structure of hepatocyte nuclei 3-6 h after the injection. These changes reach maximum by 9h, and the liver returns to its normal state by 24 h after administration. This time coincides with that of intensified new-formation of nicotinamide coenzymes (9h) and normalization of NAD content 24h in the rat liver after injection of the mentioned dose of nicotinic acid that evidence for a definite linkage of the biosynthesis processes with structures of the cell nucleus.