两根杆子和一个指南针。

Two poles and a compass.

作者信息

Meili Ruedi, Firtel Richard A

机构信息

Section of Cell and Developmental Biology, Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

出版信息

Cell. 2003 Jul 25;114(2):153-6. doi: 10.1016/s0092-8674(03)00553-1.

DOI:10.1016/s0092-8674(03)00553-1

PMID:12887916

Abstract

Rho GTPases control fundamental aspects of neutrophil chemotaxis: establishment of front and back and orientation toward the chemoattractant. Two reports in this issue show that activated Cdc42 at the leading edge helps orient the cell's axis in a signaling complex with G beta gamma, PAK1, and PIX alpha; while Rho, activated via G alpha 13, mediates formation of the uropod, which then interacts by mutual negative feedback with the front to reinforce polarization (Li et al., 2003 [this issue of Cell]; Xu et al., [this issue of Cell]).

摘要

Rho GTP酶控制中性粒细胞趋化性的基本方面：细胞前端和后端的建立以及朝向趋化因子的定向。本期的两篇报道表明，前沿激活的Cdc42在与Gβγ、PAK1和PIXα形成的信号复合物中有助于确定细胞轴的方向；而通过Gα13激活的Rho介导尾足的形成，尾足随后通过相互负反馈与前端相互作用以加强极化（Li等人，2003年[本期《细胞》杂志]；Xu等人，[本期《细胞》杂志]）。