间脑损伤会在自发交替测试期间降低海马体乙酰胆碱的释放。
Diencephalic damage decreases hippocampal acetylcholine release during spontaneous alternation testing.
作者信息
Savage Lisa M, Chang Qing, Gold Paul E
机构信息
Department of Psychology, Binghamton University, State University of New York, Binghamton, New York 13902, USA.
出版信息
Learn Mem. 2003 Jul-Aug;10(4):242-6. doi: 10.1101/lm.60003.
A rodent model of diencephalic amnesia, pyrithiamine-induced thiamine deficiency (PTD), was used to investigate diencephalic-hippocampal interactions. Acetylcholine (ACh) release, a marker of memory-related activation, was measured in the hippocampus of PTD-treated and control rats prior to, during, and after spontaneous alternation test. During behavioral testing, all animals displayed increases in ACh release. However, both the percent increase of ACh release during spontaneous alternation testing and the alternation scores were higher in control rats relative to PTD-treated rats. Thus, when rats are tested on a task with demands dependent on the hippocampus, it appears that the hippocampus is not fully activated after diencephalic damage.
使用双硫胺素诱导的硫胺素缺乏（PTD）这种间脑失忆症的啮齿动物模型来研究间脑-海马体相互作用。在自发交替试验之前、期间和之后，测量了PTD处理组和对照组大鼠海马体中乙酰胆碱（ACh）的释放情况，ACh释放是与记忆相关激活的一个标志物。在行为测试期间，所有动物的ACh释放均增加。然而，相对于PTD处理组大鼠，对照组大鼠在自发交替测试期间ACh释放的增加百分比以及交替得分均更高。因此，当大鼠在一项依赖海马体的任务上进行测试时，间脑损伤后海马体似乎并未被完全激活。
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