Uehara Eisuke, Takeuchi Seisho, Tasaka Taizo, Matsuhashi Yoshiko, Yang Yang, Fujita Mitsuhiro, Tamura Takahiro, Nagai Masami, Koeffler H Phillip
First Department of Internal Medicine, Kagawa Medical University, Miki-cho, Kagawa 761-0793, Japan.
Int J Oncol. 2003 Sep;23(3):693-6.
Methylation profile was analyzed in eleven cases of therapy-related leukemia (t-leukemia) for p14, p15, p16, Rb, hMLH1, hMSH2, MGMT, APC, RAR beta, DAPK, RIZ1, FHIT, and SOCS-1 genes by using methylation specific polymerase chain reaction (MSP) analysis. Six (55%) of eleven cases showed methylation of at least one gene. The average time to the development of t-leukemia after the treatment of the primary tumor was significantly shorter in patients with methylation than those without methylation (49.3 months vs. 133.2 months, P=0.044). These results suggest that hypermethylation might be involved in the development of t-leukemia.
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