Negative symptoms in Alzheimer's disease: a confirmatory factor analysis.
作者信息
de Jonghe Jos F M, Goedhart Arnold W, Ooms Marcel E, Kat Martin G, Kalisvaart Kees J, van Ewijk Wouter M, Ribbe Miel W
机构信息
Medical Center Alkmaar, Department of Clinical Psychology Alkmaar, The Netherlands.
出版信息
Int J Geriatr Psychiatry. 2003 Aug;18(8):748-53. doi: 10.1002/gps.917.
OBJECTIVE
To examine different conceptual models of negative symptoms in Alzheimer's disease.
DESIGN
Confirmatory factor analysis of cross-sectional data.
SUBJECTS
Alzheimer patients (n=281) admitted to a psychogeriatric observation ward.
MATERIALS
Nurses' Behavioural observation scale for psychogeriatric inpatients (GIP). Global clinical ratings of severity of dementia and depression based on the Cambridge Examination for Mental Disorders of the Elderly-Dutch version (CAMDEX-N).
RESULTS
A unidimensional model of dementia fitted the data poorly. Multidimensional models produced better results. In two- and three-factor models negative symptoms were separated from cognitive impairment and mood disturbances. The more severe the memory impairment, the more socially withdrawn patients were. In this sense negative symptoms may have been secondary to cognitive decline. However, no association was found between negative symptoms and mood disturbances.
CONCLUSIONS
Negative symptoms are a prominent clinical feature of Alzheimer's disease and they are related to memory impairment but not to mood disturbances.
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