Barr Roger C, Plonsey Robert
Department of Biomedical Engineering, Duke University, Box 90281, 136 Hudson Engineering Bldg., Durham, NC 27708-0281, USA.
IEEE Trans Biomed Eng. 2003 Aug;50(8):925-34. doi: 10.1109/TBME.2003.814529.
The cardiac electrical substrate is a challenge to direct measurement of its properties. Optical technology together with the capability to fabricate small electrodes at close spacings opens new possibilities. Here, those possibilities are explored from a theoretical viewpoint. It appears that with careful measurements from a well-designed set of electrodes one can obtain structural conductivities, separating intracellular from interstitial values, and longitudinal from transverse. Resting membrane resistance also can be obtained.
心脏电基质的特性直接测量颇具挑战。光学技术以及制造紧密间隔小电极的能力开启了新的可能性。在此,从理论角度探索这些可能性。似乎通过精心设计的一组电极进行仔细测量,能够获得结构电导率,区分细胞内和细胞间质的值,以及纵向和横向的值。静息膜电阻也能够得以获取。