Shankar P M, Dumane Vishruta A, George Thomas, Piccoli Catherine W, Reid John M, Forsberg Flemming, Goldberg Barry B
Department of Electrical and Computer Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA.
Phys Med Biol. 2003 Jul 21;48(14):2229-40. doi: 10.1088/0031-9155/48/14/313.
Classification of breast masses in greyscale ultrasound images is undertaken using a multiparameter approach. Five parameters reflecting the non-Rayleigh nature of the backscattered echo were used. These parameters, based mostly on the Nakagami and K distributions, were extracted from the envelope of the echoes at the site, boundary, spiculated region and shadow of the mass. They were combined to create a linear discriminant. The performance of this discriminant for the classification of breast masses was studied using a data set consisting of 70 benign and 29 malignant cases. The Az value for the discriminant was 0.96 +/- 0.02, showing great promise in the classification of masses into benign and malignant ones. The discriminant was combined with the level of suspicion values of the radiologist leading to an Az value of 0.97 +/- 0.014. The parameters used here can be calculated with minimal clinical intervention, so the method proposed here may therefore be easily implemented in an automated fashion. These results also support the recent reports suggesting that ultrasound may help as an adjunct to mammography in breast cancer diagnostics to enhance the classification of breast masses.
采用多参数方法对灰度超声图像中的乳腺肿块进行分类。使用了五个反映后向散射回波非瑞利特性的参数。这些参数主要基于中谷分布和K分布,从肿块的内部、边界、毛刺区域和阴影处的回波包络中提取。将它们组合以创建一个线性判别式。使用一个由70例良性病例和29例恶性病例组成的数据集研究了该判别式对乳腺肿块分类的性能。该判别式的Az值为0.96±0.02,在将肿块分为良性和恶性方面显示出很大的前景。该判别式与放射科医生的可疑度值相结合,得到的Az值为0.97±0.014。这里使用的参数可以在最少的临床干预下计算出来,因此这里提出的方法可以很容易地以自动化方式实现。这些结果也支持了最近的报告,表明超声在乳腺癌诊断中作为乳腺X线摄影的辅助手段可能有助于提高乳腺肿块的分类。