手性联萘基硫代磷酰胺-铜（I）催化二乙基锌对N-磺酰亚胺的不对称加成反应
Chiral binaphthylthiophosphoramide-cu(I)-catalyzed asymmetric addition of diethylzinc to N-sulfonylimines.
作者信息
Wang Chun-Jiang, Shi Min
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 354 Fenglin Lu, Shanghai 200032, China.
出版信息
J Org Chem. 2003 Aug 8;68(16):6229-37. doi: 10.1021/jo034269n.
In the presence of a catalytic amount of chiral binaphthylthiophosphoramide L2 (6 mol %) and Cu(I) (3 mol %), the asymmetric addition of diethylzinc to N-sulfonylimines could be achieved in good yields with moderate to high ee (63-93% ee) at 0 degrees C in toluene. A novel chiral binaphthylthiophosphoramide ligand system for this asymmetric addition reaction has been explored.
在催化量的手性联萘硫代磷酰胺L2（6摩尔%）和Cu（I）（3摩尔%）存在下，在0℃的甲苯中，二乙基锌向N-磺酰亚胺的不对称加成反应能够以良好的产率和中等至高的对映体过量（ee值为63 - 93%）实现。已经探索了用于这种不对称加成反应的新型手性联萘硫代磷酰胺配体体系。
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