Cronin Mark T D, Walker John D, Jaworska Joanna S, Comber Michael H I, Watts Christopher D, Worth Andrew P
School of Pharmacy and Chemistry, Liverpool John Moores University, Liverpool, England.
Environ Health Perspect. 2003 Aug;111(10):1376-90. doi: 10.1289/ehp.5759.
This article is a review of the use, by regulatory agencies and authorities, of quantitative structure-activity relationships (QSARs) to predict ecologic effects and environmental fate of chemicals. For many years, the U.S. Environmental Protection Agency has been the most prominent regulatory agency using QSARs to predict the ecologic effects and environmental fate of chemicals. However, as increasing numbers of standard QSAR methods are developed and validated to predict ecologic effects and environmental fate of chemicals, it is anticipated that more regulatory agencies and authorities will find them to be acceptable alternatives to chemical testing.
本文是对监管机构运用定量构效关系(QSARs)预测化学品的生态效应和环境归宿的综述。多年来,美国环境保护局一直是运用QSARs预测化学品的生态效应和环境归宿的最突出监管机构。然而,随着越来越多用于预测化学品的生态效应和环境归宿的标准QSAR方法得到开发和验证,预计会有更多的监管机构认为它们是化学测试的可接受替代方法。