Vāvere A L, Lewis J S
Department of Chemistry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Q J Nucl Med. 2003 Sep;47(3):163-70.
It is clear that various imaging modalities have given keen insight into the molecular mechanisms involved in anti-angiogenic treatments. A key to the advancement of anti-angiogenic therapy is not only the discovery of new drugs and treatments, but the analysis of the specific modes of action of these compounds in order to produce the next generation with greater effectiveness. While existing clinical methods incorporate the analysis of serum and urine to measure angiogenic factors, an imaging technique monitoring the effectiveness of anti-angiogenic therapy would be a convenient, noninvasive, cost effective technique to aid in treatment planning and disease management.
很明显，各种成像方式已经让我们深入了解了抗血管生成治疗所涉及的分子机制。抗血管生成治疗取得进展的关键不仅在于发现新的药物和治疗方法，还在于分析这些化合物的具体作用模式，以便开发出更有效的新一代治疗方法。虽然现有的临床方法包括分析血清和尿液来测量血管生成因子，但一种监测抗血管生成治疗效果的成像技术将是一种方便、无创且具有成本效益的技术，有助于治疗规划和疾病管理。
