(2'R)-[2'-2H]-脱氧核糖核苷的高度立体选择性合成及其寡核苷酸的合成。
Highly stereoselective synthesis of (2'R)-[2'-2H]-deoxyribonucleosides and synthesis of their oligonucleotides.
作者信息
Kawashima E, Sekine T, Miyahara M, Aoyama Y, Hirao I, Kainosho M, Kyogoku Y, Ishido Y
机构信息
Laboratory of Pharmaceutical Chemistry, Tokyo College of Pharmacy, Japan.
出版信息
Nucleic Acids Symp Ser. 1992(27):81-2.
PMID:1289834
Abstract
Highly stereoselective synthesis of (2'R)-[2'-2H]-2'-deoxyribonucleosides (2'R:2'S = > 99:1) were accomplished by treating 2'-bromo-3',5'-O-TPDS-2'-deoxyribonucleosides with tributyltin deuteride at lower temperatures such as -60 degrees C in the presence of triethylborane. Moreover, synthesis of some oligodeoxyribonucleosides involving them will be described.
摘要
通过在三乙基硼存在下于较低温度（如-60℃）用氘代三丁基锡处理2'-溴-3',5'-O-三苯基硅基-2'-脱氧核糖核苷，实现了(2'R)-[2'-2H]-2'-脱氧核糖核苷（2'R:2'S＞99:1）的高度立体选择性合成。此外，还将描述一些涉及它们的寡脱氧核糖核苷的合成。
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