Bachar Gil N, Greif Franklin, Mor Eytan, Tur-Kaspa Ran, Belenky Alexander
Departments of Radiology (Interventional Radiology Unit), Rabin Medical Center (Beilinson Campus), Petah Tiqva, Israel.
Isr Med Assoc J. 2003 Jul;5(7):496-500.
Radiofrequency ablation has recently become a viable treatment option for unresectable primary or secondary lesions confined to the liver.
To study the local therapeutic efficacy, side effects and complications of radiofrequency ablation for the treatment of hepatocellular carcinoma and liver metastases. This is the first reported experience of radiofrequency ablation for treating malignant hepatic tumors in Israel.
Fifteen consecutive patients, aged 53-73 years, with 23 lesions (8 patients with HCC and 7 with secondary liver tumors) underwent radiofrequency ablation under general anesthesia. RITA nine-array 5 cm thermal ablation catheter and the model 1500 generator were used. The mean diameter of all tumors was 4.28 cm (range 1-10 cm). Three lesions were 1-3 cm in diameter (small), 17 lesions measured 3.1-5 cm (medium), and 3 measured 5.1-10 cm (large).
Complete necrosis was found in 8 (66%) of 12 HCCs by computed tomography scan. Of the remainder, diffuse tumor recurrence was demonstrated in three lesions (25%) after lipiodol injection and there was one local tumor recurrence. In the metastases group complete necrosis was found in 5 of 11 lesions (45%). One major complication (peritonitis) was treated with antibiotics and four (26%) minor complications (right pleural effusion, small subcapsular hematoma) were monitored.
Radiofrequency ablation appears to be an effective, safe and relatively simple procedure for the treatment of liver tumors.
射频消融术最近已成为治疗局限于肝脏的不可切除原发性或继发性病灶的一种可行治疗选择。
研究射频消融术治疗肝细胞癌和肝转移瘤的局部治疗效果、副作用及并发症。这是以色列首次报道的射频消融术治疗肝脏恶性肿瘤的经验。
15例年龄在53至73岁之间的连续患者，共23个病灶（8例肝细胞癌患者和7例继发性肝肿瘤患者）在全身麻醉下接受射频消融术。使用RITA九阵列5厘米热消融导管和1500型发生器。所有肿瘤的平均直径为4.28厘米（范围1至10厘米）。3个病灶直径为1至3厘米（小），17个病灶直径为3.1至5厘米（中），3个病灶直径为5.1至10厘米（大）。
通过计算机断层扫描，12例肝细胞癌中有8例（66%）出现完全坏死。其余病例中，3个病灶（25%）在注射碘油后出现弥漫性肿瘤复发，1例出现局部肿瘤复发。在转移瘤组中，11个病灶中有5例（45%）出现完全坏死。1例主要并发症（腹膜炎）用抗生素治疗，4例（26%）轻微并发症（右侧胸腔积液、小的包膜下血肿）进行了监测。
射频消融术似乎是一种治疗肝脏肿瘤的有效、安全且相对简单的方法。
