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蚊子基因组——一个转折点?

The mosquito genome--a turning point?

作者信息

Kanzok Stefan M, Zheng Liangbiao

机构信息

Yale School of Medicine, Department of Epidemiology and Public Health, 60 College Street, New Haven, CT 06520, USA.

出版信息

Trends Parasitol. 2003 Aug;19(8):329-31. doi: 10.1016/s1471-4922(03)00145-4.

Abstract

Of the insects that serve as vectors for parasitic diseases, the genus Anopheles is the most important. Of the approximately 400 species, about twelve serve as vectors for human pathogens. Months have passed since the sequenced genomes of the malaria parasite, Plasmodium falciparum, and its vector, Anopheles gambiae, were published. Sequences were compared, gene and protein predictions were made, new research areas evolved and many ongoing projects gained new momentum. A general belief is that we are at a turning point: we are now in a position to tackle both the parasite and the vector from new angles and with new force, for example, by identifying new drug targets and obtaining a deeper insight into molecular mechanisms of the insect, the parasite and the interactions between them.

摘要

在作为寄生虫病传播媒介的昆虫中,按蚊属最为重要。在大约400个物种中,约有12种充当人类病原体的传播媒介。自疟原虫(恶性疟原虫)及其传播媒介冈比亚按蚊的基因组测序公布以来,已经过去了数月。对序列进行了比较,进行了基因和蛋白质预测,新的研究领域不断涌现,许多正在进行的项目也获得了新的动力。人们普遍认为,我们正处于一个转折点:我们现在有能力从新的角度、以新的力度来对付寄生虫和传播媒介,例如,通过识别新的药物靶点以及更深入地了解昆虫、寄生虫及其相互作用的分子机制。

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