Zhou X Q, Liu X Q, Kong J C
Department of Neurology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001 Oct;23(5):455-7.
To make an inquiry into clinical features, treatment, and prognosis of primary central nervous system lymphoma (PCNSL).
A retrospective analysis was carried out in a group of 8 patients confirmed diagnostic PCNSL by clinical findings and pathological examination.
The common clinical manifestation of PCNSL consisted of increased intracranial pressure, seizures, focal neurologic deficits. Studies of cerebrospinal fluid revealed protein elevation in the most patients. Neuroradiological examinations with CT and MRI both showed solitary or multiple lesion located cerebral hemisphere, periventricular, basal ganglia, corpus callosum. Pathological examination showed B-cell malignant lymphoma.
The patients with PCNSL usually did not show characteristic clinical manifestations or findings in imaging scanning. The brain biopsy pathological examination might be the only reliable method to confirm the diagnosis of the disease.
探讨原发性中枢神经系统淋巴瘤（PCNSL）的临床特征、治疗方法及预后。
对一组8例经临床检查及病理检查确诊为PCNSL的患者进行回顾性分析。
PCNSL的常见临床表现为颅内压升高、癫痫发作、局灶性神经功能缺损。脑脊液检查显示大多数患者蛋白升高。CT和MRI神经影像学检查均显示位于脑半球、脑室周围、基底节、胼胝体的单发或多发病变。病理检查显示为B细胞恶性淋巴瘤。
PCNSL患者通常无特征性临床表现或影像学扫描表现。脑活检病理检查可能是确诊该病的唯一可靠方法。
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