Cook Stephen, Weitzman Michael, Auinger Peggy, Nguyen Michael, Dietz William H
Strong Children's Research Center, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, NY 14642, USA.
Arch Pediatr Adolesc Med. 2003 Aug;157(8):821-7. doi: 10.1001/archpedi.157.8.821.
In adults the metabolic syndrome imposes a substantial risk for type 2 diabetes mellitus and premature coronary heart disease. Even so, no national estimate is currently available of the prevalence of this syndrome in adolescents.
To estimate the prevalence and distribution of a metabolic syndrome among adolescents in the United States.
Analyses of cross-sectional data obtained from the Third National Health and Nutrition Examination Survey (1988-1994), which was administered to a representative sample of the noninstitutionalized civilian population of the United States.
Male and female respondents aged 12 to 19 years (n = 2430).
The prevalence and distribution of a metabolic syndrome among US adolescents, using the National Cholesterol Education Program (Adult Treatment Panel III) definition modified for age.
The overall prevalence of the metabolic syndrome among adolescents aged 12 to 19 years was 4.2%; 6.1% of males and 2.1% of females were affected (P=.01). The syndrome was present in 28.7% of overweight adolescents (body mass index [BMI], >/=95th percentile) compared with 6.8% of at-risk adolescents (BMI, 85th to <95th percentile) and 0.1% of those with a BMI below the 85th percentile (P<.001). Based on population-weighted estimates, approximately 910 000 US adolescents have the metabolic syndrome.
Perhaps 4% of adolescents and nearly 30% of overweight adolescents in the United States meet these criteria for a metabolic syndrome, a constellation of metabolic derangements associated with obesity. These findings may have significant implications for both public health and clinical interventions directed at this high-risk group of mostly overweight young people.
在成年人中，代谢综合征会带来患2型糖尿病和早发性冠心病的重大风险。即便如此，目前尚无关于该综合征在青少年中患病率的全国性评估。
评估美国青少年中代谢综合征的患病率及分布情况。
对第三次全国健康与营养检查调查（1988 - 1994年）获取的横断面数据进行分析，该调查针对美国非机构化平民人口的代表性样本开展。
年龄在12至19岁的男性和女性受访者（n = 2430）。
采用针对年龄修改后的国家胆固醇教育计划（成人治疗小组第三次报告）定义，评估美国青少年中代谢综合征的患病率及分布情况。
12至19岁青少年中代谢综合征的总体患病率为4.2%；男性患病率为6.1%，女性患病率为2.1%（P = 0.01）。超重青少年（体重指数[BMI]≥第95百分位数）中该综合征的患病率为28.7%，而处于风险中的青少年（BMI为第85至<95百分位数）患病率为6.8%，BMI低于第85百分位数的青少年患病率为0.1%（P<0.001）。根据人口加权估计，美国约有91万青少年患有代谢综合征。
美国约4%的青少年以及近30%的超重青少年符合代谢综合征的这些标准，这是一组与肥胖相关的代谢紊乱症候群。这些发现可能对针对这一以超重年轻人为主的高危群体的公共卫生和临床干预具有重大意义。
