基于组装诱导折叠的双链折叠体

Duplex foldamers from assembly induced folding.

作者信息

Yang Xiaowu, Martinovic Suzana, Smith Richard D, Gong Bing

机构信息

Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

出版信息

J Am Chem Soc. 2003 Aug 20;125(33):9932-3. doi: 10.1021/ja0361897.

DOI:10.1021/ja0361897

PMID:12914450

Abstract

Oligoamide strands 1, 2, and 3, consisting of 4-H-bond units, were originally designed to form noncovalent polymers based on the expectation that they would adopt an extended conformation. Instead of assembling into the expected supramolecular polymer through their 4-H-bond units, the 1:1 mixture of 1 and 2 was found to form a highly stable dimeric species. To dimerize, the H-bonding sequences of 1 and 2 can only adopt a folded (stacked) conformation. The self-assembly of 3 was also found to adopt a similar folded duplex conformation. These novel duplex foldamers are very stable. They were characterized by 1D and 2D 1H NMR, VPO, and mass spectral (ESI) studies.

摘要

由4-H键单元组成的寡酰胺链1、2和3最初被设计用于形成非共价聚合物，基于它们会采取伸展构象的预期。然而，1和2的1:1混合物并未通过其4-H键单元组装成预期的超分子聚合物，而是形成了一种高度稳定的二聚体物种。为了二聚化，1和2的氢键序列只能采取折叠（堆叠）构象。还发现3的自组装也采取类似的折叠双链构象。这些新型双链折叠体非常稳定。它们通过一维和二维1H NMR、VPO和质谱（ESI）研究进行了表征。