The relevance of prolonged QTc measurement to pediatric psychopharmacology.

OBJECTIVE

To consider the relevance of prolonged QTc (QT interval corrected for rate) to pediatric psychopharmacology.

METHOD

The authors reviewed publications on QTc prolongation and publications on sudden death in Medline from 1968 to November 2002.

RESULTS

The search yielded more than 20,000 publications. Review manuscripts with clinical recommendations outnumber the few pediatric studies of QTc duration during treatment. Most reviews have been published in the past 5 years, during a time when the Food and Drug Administration restricted five psychotropic medications because of QTc prolongation (sertindole: not approved; thioridazine, mesoridazine, and droperidol: black-box warning; and ziprasidone: bolded warning) and nine somatic medications because of QTc prolongation.

CONCLUSION

Pretreatment screening, careful selection of psychotropic and/or somatic medication combinations, and recognition of QTc prolongation in electrocardiographic tracings during treatment with medications that prolong QTc are important components of clinical practice.