Shen Qing, Gan Hua, Du Xiao-gang, Li Zheng-rong, Chen Deng-ju
Department of Nephrology, The First Hospital, Chongqing Medical University, Chongqing 400016, China.
Zhonghua Nei Ke Za Zhi. 2003 Jul;42(7):483-5.
To observe the efficacy of continuous veno-venous hemofiltration (CVVH) in the treatment of severe acute pancreatitis (SAP).
Fifty three patients with SAP were involved, CVVH was performed for at least 24 hours. During CVVH, the patients' conditions and pancreatic enzymes (amylase and lipase) were observed, serum concentration of endotoxin was measured as well.
After CVVH, the symptoms of patients such as tachycardia, respiratory distress, and abdominal pain were remitted. The APACHE II score decreased significantly. Six hours after CVVH, serum concentration of endotoxin was decreased significantly. Fifteen patients died, the mortality rate was 28.3%.
CVVH could decrease the mortality rate of SAP with multiple organ dysfunction syndrome.
观察持续静脉-静脉血液滤过（CVVH）治疗重症急性胰腺炎（SAP）的疗效。
纳入53例SAP患者，进行CVVH治疗至少24小时。在CVVH治疗期间，观察患者病情及胰腺酶（淀粉酶和脂肪酶），并检测血清内毒素浓度。
CVVH治疗后，患者心动过速、呼吸窘迫和腹痛等症状缓解。急性生理与慢性健康状况评分系统（APACHE II）评分显著降低。CVVH治疗6小时后，血清内毒素浓度显著降低。15例患者死亡，死亡率为28.3%。
CVVH可降低合并多器官功能障碍综合征的SAP患者的死亡率。
