Jung W H, Yang W I, Park C, Choi I J
Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 1992 Sep;33(3):249-57. doi: 10.3349/ymj.1992.33.3.249.
Flow cytometric DNA analysis was performed on 19 adrenal pheochromocytomas and 6 extra-adrenal paragangliomas in parallel with clinical and histopathological review to determine the usefulness of this technique to predict biologic behavior of these tumors. In pheochromocytomas and paragangliomas, tetraploidy or near-tetraploidy occurred in 32% and 33% and aneuploidy in 10% and none respectively. A case of malignant pheochromocytoma had diploid DNA content. Occurrence of aneuploidy or tetraploidy is frequent in clinically benign tumors in conjunction with a marked degree of nuclear atypia and cannot be a predictor of malignancy.
对19例肾上腺嗜铬细胞瘤和6例肾上腺外副神经节瘤进行了流式细胞术DNA分析，并与临床和组织病理学检查同步进行，以确定该技术对预测这些肿瘤生物学行为的实用性。在嗜铬细胞瘤和副神经节瘤中，四倍体或近四倍体分别出现在32%和33%的病例中，非整倍体分别出现在10%的嗜铬细胞瘤病例中，而副神经节瘤中未出现非整倍体。1例恶性嗜铬细胞瘤的DNA含量为二倍体。非整倍体或四倍体在临床上为良性的肿瘤中经常出现，同时伴有明显的核异型性，因此不能作为恶性肿瘤的预测指标。
