自交联透明质酸凝胶预防宫腔镜粘连松解术后宫腔粘连的有效性：一项前瞻性、随机、对照研究。
Effectiveness of auto-cross-linked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic adhesiolysis: a prospective, randomized, controlled study.
作者信息
Acunzo Giuseppe, Guida Maurizio, Pellicano Massimiliano, Tommaselli Giovanni Antonio, Di Spiezio Sardo Attilio, Bifulco Giuseppe, Cirillo Domenico, Taylor Alex, Nappi Carmine
机构信息
Department of Obstetrics and Gynaecology, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
出版信息
Hum Reprod. 2003 Sep;18(9):1918-21. doi: 10.1093/humrep/deg368.
BACKGROUND
A prospective, randomized, controlled study was performed to assess the efficacy of auto-cross-linked hyaluronic acid (ACP) gel in preventing the development of intrauterine adhesions following hysteroscopic adhesiolysis.
METHODS
Ninety-two patients with irregular menses and intrauterine adhesions referred to the Hysteroscopic Unit of the University of Naples "Federico II". Patients were randomized to two different groups. Group A were randomized to hysteroscopic adhesiolysis plus intrauterine application of ACP gel (10 ml) and group B were randomized to operative hysteroscopy alone (control group). Baseline adhesion scores were calculated for each patient and at 3 months after surgery.
RESULTS
Group A showed a significant decrease in intrauterine adhesions at 3 months follow-up in comparison with the control group. Staging of adhesions showed a significant decrease in adhesion severity in patients treated with ACP gel.
CONCLUSIONS
ACP gel significantly reduces the development of intrauterine adhesions postoperatively and its use is likely to be associated with a reduction of severe adhesions.
背景
进行了一项前瞻性、随机对照研究，以评估自交联透明质酸（ACP）凝胶在宫腔镜粘连松解术后预防宫腔粘连形成中的疗效。
方法
92例月经不规律且有宫腔粘连的患者转诊至那不勒斯费德里科二世大学宫腔镜科。患者被随机分为两组。A组被随机分配接受宫腔镜粘连松解术加宫腔内应用ACP凝胶（10毫升），B组被随机分配仅接受宫腔镜手术（对照组）。计算每位患者的基线粘连评分以及术后3个月时的粘连评分。
结果
与对照组相比，A组在3个月随访时宫腔粘连明显减少。粘连分期显示，接受ACP凝胶治疗的患者粘连严重程度显著降低。
结论
ACP凝胶可显著减少术后宫腔粘连的形成，其使用可能与严重粘连的减少有关。
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