解密Cripto在肿瘤发生中的作用。
Decrypting the role of Cripto in tumorigenesis.
作者信息
Shen Michael M
机构信息
Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, New Jersey 08854, USA.
出版信息
J Clin Invest. 2003 Aug;112(4):500-2. doi: 10.1172/JCI19546.
Abstract
The cell-surface associated molecule Cripto is overexpressed in a wide range of epithelial cancers, yet little is known about potential mechanisms by which Cripto expression might enhance tumorigenesis. A new study reveals that binding of Cripto to the TGF-beta ligand Activin B can block Activin B-mediated suppression of cell proliferation. Furthermore, this study also demonstrates that antibody blockade of Cripto function may prove useful in the inhibition of tumorigenesis.
摘要
细胞表面相关分子Cripto在多种上皮癌中过度表达，但对于Cripto表达可能增强肿瘤发生的潜在机制却知之甚少。一项新研究表明，Cripto与转化生长因子-β配体激活素B结合可阻断激活素B介导的细胞增殖抑制作用。此外，该研究还证明，对Cripto功能进行抗体阻断可能对抑制肿瘤发生有用。
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本文引用的文献
1
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2
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Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5193-8. doi: 10.1073/pnas.0531290100. Epub 2003 Apr 7.
3
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