Sodeyama M, Kirk S J, Regan M C, Barbul A
Department of Surgery, Sinai Hospital, Baltimore, MD 21215.
Circ Shock. 1992 Nov;38(3):153-6.
Hemorrhagic shock causes a disproportionate decrease in portal blood flow which may adversely affect the barrier and absorptive functions of the intestine. The absorptive capacity of the small intestine was studied during shock induced by mild and severe hemorrhage in the rat by measurement of the uptake of a radiolabelled amino acid analog (aminoisobutyric acid: AIB). Hemorrhage resulted in a significant reduction in systemic blood pressure, portal blood flow, and the absorption of AIB from the small intestine. Resuscitation restored both blood pressure and portal blood flow. But a significant reduction in absorption of AIB persisted. This suggests that hemorrhage results in an inhibition of amino acid intestinal active transport which is not dependent on the mesenteric circulation. The reduced intestinal absorptive function has important implications for the route of administration of nutrition following hemorrhage and trauma.
失血性休克导致门静脉血流量不成比例地减少，这可能会对肠道的屏障和吸收功能产生不利影响。通过测量放射性标记的氨基酸类似物（氨基异丁酸：AIB）的摄取量，研究了大鼠在轻度和重度出血诱导的休克期间小肠的吸收能力。出血导致全身血压、门静脉血流量以及小肠对AIB的吸收显著降低。复苏使血压和门静脉血流量均恢复正常。但AIB的吸收仍持续显著降低。这表明出血导致氨基酸肠道主动转运受到抑制，且这种抑制不依赖于肠系膜循环。肠道吸收功能降低对出血和创伤后营养物质的给药途径具有重要意义。
