Hemoglobin heterogeneity under conditions of abnormal erythropoiesis.

作者信息

Sumin M N, Rezaikin A V, Yushkov B G

机构信息

Ekaterinburg Branch of the Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Ekaterinburg.

出版信息

Bull Exp Biol Med. 2003 Jun;135(6):563-5. doi: 10.1023/a:1025477202093.

DOI:10.1023/a:1025477202093

PMID:12937674

Abstract

Experiments on rats showed that changes in the hemoglobin profile during hypoxia are determined by switching of erythropoiesis from the "basic" to "emergency" mode. The "basic" mode of erythropoiesis is typical of the mature organism under normal conditions. The "reserve" or "emergency" mode is realized in fetuses, senile animals, and during hypoxia. This mode is characterized by production of large erythrocytes with high content of fetal hemoglobin.

摘要