Karimov Kh Ya, Inoyatova F Kh, Mukhamedova M T
Central Scientific Laboratory, Second Tashkent State Medical Institute, Tashkent, Republic of Uzbekistan.
Exp Toxicol Pathol. 2003 Jul;55(1):17-9. doi: 10.1078/0940-2993-00267.
Our objective in this study was to determine some indices of the synthesis of nitric oxide during the early periods of diethylnitrosamine-induced hepatocarcinogenesis in mature male rats and to gain insights into their relationship to lipid peroxidation. The basis for the study was the intragastric administration of 10 mg/kg diethylnitrosamine 5 times a week for two months to 28 male rats; 12 additional rats served as untreated controls. During the time-related course of hepatocarcinogenesis, the blood serum level of L-arginine was found to decrease significantly while that of malondialdehyde tended to increase. The superoxide dismutase (SOD) activity increased somewhat during the period of initiation. A significant reduction of SOD was recorded during the period of promotion and a striking increase occurred in the initial period of progression. Unlike SOD, catalase showed a tendency to increase after some initial decline in its activity.
我们在本研究中的目标是确定成熟雄性大鼠二乙基亚硝胺诱导肝癌发生早期一氧化氮合成的一些指标，并深入了解它们与脂质过氧化的关系。本研究的基础是每周5次给28只雄性大鼠胃内注射10mg/kg二乙基亚硝胺，持续两个月；另外12只大鼠作为未处理对照。在肝癌发生的时间相关过程中，发现血清中L-精氨酸水平显著降低，而丙二醛水平则有升高趋势。超氧化物歧化酶（SOD）活性在启动期有所增加。在促进期记录到SOD显著降低，在进展期初期则显著增加。与SOD不同，过氧化氢酶在其活性最初有所下降后呈现出增加的趋势。
