三种不同纯化方法用于常规制备[11C]美托咪酯的比较。

Comparison of three different purification methods for the routine preparation of [11C] Metomidate.

作者信息

Mitterhauser Markus, Wadsak Wolfgang, Langer Oliver, Schmaljohann Joern, Zettinig Georg, Dudczak Robert, Viernstein Helmut, Kletter Kurt

机构信息

Department of Nuclear Medicine, University of Vienna, AKH Wein, Waehringer Guertel 18-20, 1090 Vienna, Austria.

出版信息

Appl Radiat Isot. 2003 Aug-Sep;59(2-3):125-8. doi: 10.1016/s0969-8043(03)00168-4.

DOI:10.1016/s0969-8043(03)00168-4

PMID:12941500

Abstract

PET with (R)-[O-methyl-11C] metomidate ([11C] MTO) is an attractive method for the characterisation of adrenal masses discriminating lesions of adrenal cortical origin from noncortical lesions. [11C] MTO was prepared by the reaction of [11C] methyliodide with the corresponding free acid. Three purification methods have been compared. The method of choice uses preparative HPLC with a ready-to-use weak acidic solvent.

摘要

使用（R）-[O-甲基-11C]米托咪酯（[11C] MTO）的正电子发射断层扫描（PET）是一种用于鉴别肾上腺肿块、区分肾上腺皮质来源病变与非皮质病变的有吸引力的方法。[11C] MTO通过[11C]甲基碘与相应的游离酸反应制备。比较了三种纯化方法。首选方法是使用配备即用型弱酸性溶剂的制备型高效液相色谱法。