通过变性高效液相色谱法检测的脱脚病病毒分离株中免疫调节基因的遗传变异性。
Genetic variability of immunomodulatory genes in ectromelia virus isolates detected by denaturing high-performance liquid chromatography.
作者信息
Ribas Gloria, Rivera Jose, Saraiva Margarida, Campbell R Duncan, Alcami Antonio
机构信息
MRC UK HGMP Resource Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SB, UK.
出版信息
J Virol. 2003 Sep;77(18):10139-46. doi: 10.1128/jvi.77.18.10139-10146.2003.
Abstract
The genetic variability of nine genes in 12 isolates and strains of ectromelia virus, which causes a smallpox-like disease (mousepox) in mice, was determined and allows for classification of ectromelia viruses. The low genetic variability suggests that evolutionary pressure maintains the activity of immunomodulatory genes in natural poxvirus infections.
摘要
在12株引起小鼠患类似天花疾病（鼠痘）的痘苗病毒分离株和菌株中，测定了9个基因的遗传变异性，这有助于对痘苗病毒进行分类。低遗传变异性表明进化压力维持了天然痘病毒感染中免疫调节基因的活性。
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