氟代亲双烯体在狄尔斯-阿尔德反应中是强大的双烯捕获剂。
Fluorous dienophiles are powerful diene scavengers in Diels-Alder reactions.
作者信息
Werner Stefan, Curran Dennis P
机构信息
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
出版信息
Org Lett. 2003 Sep 4;5(18):3293-6. doi: 10.1021/ol035214a.
PMID:12943410
Abstract
[reaction: see text] Three fluorous dienophiles have been synthesized, and their value in scavenging an excess diene after Diels-Alder reactions is shown. The resulting fluorous derivatives are separated by solid-phase extraction on fluorous silica gel (FSPE). The fluorous [1,2,4]triazoline-3,5-dione 10 reacted with most dienes within seconds or minutes.
摘要
[反应：见正文] 已合成了三种含氟亲双烯体，并展示了它们在狄尔斯-阿尔德反应后清除过量双烯方面的价值。通过在含氟硅胶上进行固相萃取（FSPE）分离得到的含氟衍生物。含氟的[1,2,4]三唑啉-3,5-二酮10能在几秒或几分钟内与大多数双烯发生反应。
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