Theocharis S E, Kouraklis G P, Kakisis J D, Kanelli H G, Apostolakou F E, Karatzas G M, Koutselinis A S
Department of Forensic Medicine and Toxicology, Medical School, University of Athens, 75, Mikras Asias street, GR 11527, Athens, Greece.
Eur J Surg Oncol. 2003 Sep;29(7):571-4. doi: 10.1016/s0748-7983(03)00120-3.
Focal adhesion kinase (FAK) is an enzyme of the tyrosine kinase group linked to signaling pathways between cells and their extracellular matrix. FAK expression in tumor cells in vitro may correlate with their ability for invasion and metastasis.
FAK protein expression was examined immunohistochemically in 80 cases of colon adenocarcinoma, and correlated with clinicopathological parameters; tumor proliferative capacity, reflected by Ki-67 antigen expression; and survival.
All tumor samples were FAK positive compared to normal colonic mucosa. FAK protein overexpression was seen in 32 out of 80 cases. FAK protein overexpression did not correlated with tumor histological grade, stage, Ki-67 positivity or survival.
Raised FAK protein expression was noted by immunohistochemistry in human colon carcinoma cases. The implication are discussed.
粘着斑激酶（FAK）是一种酪氨酸激酶类酶，与细胞及其细胞外基质之间的信号通路相关。体外肿瘤细胞中FAK的表达可能与其侵袭和转移能力相关。
采用免疫组织化学方法检测80例结肠腺癌中FAK蛋白表达，并与临床病理参数、由Ki-67抗原表达反映的肿瘤增殖能力以及生存率进行相关性分析。
与正常结肠黏膜相比，所有肿瘤样本FAK均呈阳性。80例中有32例出现FAK蛋白过表达。FAK蛋白过表达与肿瘤组织学分级、分期、Ki-67阳性或生存率均无相关性。
免疫组织化学检测发现人结肠癌病例中FAK蛋白表达升高。对其意义进行了讨论。
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