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[职业风险:乙型肝炎。综合医院的疫苗接种策略]

[Professional risk: hepatitis B. Vaccination strategies in a general hospital].

作者信息

Frider B, Sookoian S, Rebora N, Castaño G, Rozenblat E

机构信息

Hospital General de Agudos C. Argerich, Unidad Clinica Médica A, Hepatologia, Buenos Aires, Argentina.

出版信息

Acta Gastroenterol Latinoam. 1992;22(1):29-35.

PMID:1295285
Abstract

The risk of contracting hepatitis B: (HBV) by health workers is widely accepted. In 1989 our Hepatology Service started a voluntary anti-HBV vaccination program, employing recombinant vaccine (SKF) by intramuscular route with a 0-1-6 month schedule after screening with antibody against the anti-core HBV antigen (AntiHBc Elisa Abbott). Initially, it was planned to monitor antibody titers against superficial antigen (Anti-HBs) 30 days after the last dose. An epidemiological form listing personal data, working area, profession, seniority, written consent for blood extraction and tentative acceptance of vaccination, was completed by 357 hospital staff members. After serological screening, only 184 (51%) workers agreed to receive vaccination. Given the paucity of volunteers, an attempt was made to explain this degree of reluctance by a randomized blind voluntary survey, to which 349 hospital staff members and 40 medical students replied. Questions were related to knowledge concerning vaccination in general, hepatitis and particularly hepatitis B, and specific anti-HBV vaccination. An appraisal of data gathered disclosed a considerable lack of information not only on the risk of HBV infection and its complications, but also on the existence of a suitable vaccine. Non-existent adverse effects of vaccination were mentioned, including AIDS (Acquired Immuno-Deficiency Syndrome), hepatitis and cirrhosis, among others. To overcome this obstacle, we held a two-day workshop on hepatitis B prevention and prophylaxis intended for medical and ancillary staff. After the meeting, which were attended by 221 members, 48 individuals, comprising 25 physicians and 23 nurses, spontaneously requested to be vaccinated.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

医护人员感染乙型肝炎病毒(HBV)的风险已被广泛认可。1989年,我们的肝病科启动了一项自愿性抗HBV疫苗接种计划,采用重组疫苗(SKF),通过肌肉注射途径,按照0-1-6月的时间表接种,接种前先用抗核心HBV抗原抗体(抗HBc酶联免疫吸附测定法,雅培试剂)进行筛查。最初计划在最后一剂接种后30天监测抗表面抗原抗体(抗HBs)滴度。357名医院工作人员填写了一份流行病学表格,列出个人数据、工作区域、职业、工作年限、抽血书面同意书以及初步接种意愿。血清学筛查后,只有184名(51%)工作人员同意接种疫苗。鉴于志愿者数量稀少,我们试图通过一项随机盲法自愿调查来解释这种不情愿的程度,349名医院工作人员和40名医学生参与了该调查。问题涉及一般疫苗接种、肝炎尤其是乙型肝炎以及特定抗HBV疫苗接种的相关知识。对收集到的数据进行评估后发现,不仅关于HBV感染风险及其并发症,而且关于合适疫苗的存在,都存在相当大的信息缺失。还提到了不存在的疫苗不良反应,包括艾滋病(获得性免疫缺陷综合征)、肝炎和肝硬化等。为克服这一障碍,我们为医护人员举办了为期两天的乙型肝炎预防研讨会。会议有221名成员参加,会后,48人自发要求接种疫苗,其中包括25名医生和23名护士。(摘要截选至250字)

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