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格陵兰人冠状动脉和主动脉的动脉粥样硬化:一项尸检研究。

Atherosclerosis in coronary arteries and aorta among Greenlanders: an autopsy study.

作者信息

Pedersen Henning Sloth, Mulvad Gert, Newman William P, Boudreau Donald A

机构信息

The Primary Health Care Clinic, P.O. Box 1001, DK-3900 Nuuk, Greenland.

出版信息

Atherosclerosis. 2003 Sep;170(1):93-103. doi: 10.1016/s0021-9150(03)00240-5.

Abstract

In a cross-sectional autopsy study of 107 Inuit in Greenland, the extent of arterial surface involvement with atherosclerosis was evaluated in the presence of known or estimated environmental risk factors for coronary heart disease (CHD): age, gender, obesity, serum lipids, smoking, and hypertension. Mean, median, and range values for all of the risk factor variables and for the extent of atherosclerosis in the thoracic aorta, abdominal aorta, right coronary artery, and left anterior descending coronary artery are reported by age strata, along with the results of covariant analysis of the dependence of the extent of atherosclerosis upon the risk factors. No significant differences between females and males were found in either the risk factors or prevalence and extent of atherosclerosis in the aorta and in the coronary arteries. It appears that the extent of advanced atherosclerotic lesions in Greenlanders appears to be the same as that previously reported in a similar study in Alaska Natives.

摘要

在一项对格陵兰岛107名因纽特人的横断面尸检研究中,在已知或估计的冠心病(CHD)环境危险因素(年龄、性别、肥胖、血脂、吸烟和高血压)存在的情况下,评估了动脉表面动脉粥样硬化的累及程度。按年龄分层报告了所有危险因素变量以及胸主动脉、腹主动脉、右冠状动脉和左前降支冠状动脉中动脉粥样硬化累及程度的均值、中位数和范围值,以及动脉粥样硬化累及程度对危险因素依赖性的协变量分析结果。在主动脉和冠状动脉的危险因素、动脉粥样硬化患病率及累及程度方面,未发现女性和男性之间存在显著差异。格陵兰人晚期动脉粥样硬化病变的程度似乎与之前在阿拉斯加原住民的类似研究中报告的程度相同。

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