MSR1的种系改变与前列腺癌风险无关联。

No association of germline alteration of MSR1 with prostate cancer risk.

作者信息

Wang Liang, McDonnell Shannon K, Cunningham Julie M, Hebbring Scott, Jacobsen Steven J, Cerhan James R, Slager Susan L, Blute Michael L, Schaid Daniel J, Thibodeau Stephen N

机构信息

Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, 920 Hilton Building, Mayo Clinic and Foundation, Rochester, Minnesota, USA.

出版信息

Nat Genet. 2003 Oct;35(2):128-9. doi: 10.1038/ng1239. Epub 2003 Sep 7.

DOI:10.1038/ng1239

PMID:12958598

Abstract

The macrophage scavenger receptor 1 gene (MSR1) was recently identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer. To confirm these findings, we screened MSR1 for germline mutations among individuals with familial prostate cancer and tested gene variants for associations in both sporadic and familial prostate cancer. Our results do not support MSR1 as a risk factor for prostate cancer.

摘要

巨噬细胞清道夫受体1基因（MSR1）最近被确定为遗传性前列腺癌的候选易感基因以及散发性前列腺癌的一个风险因素。为了证实这些发现，我们在家族性前列腺癌患者中筛查了MSR1的种系突变，并检测了该基因变异在散发性和家族性前列腺癌中的关联性。我们的结果并不支持MSR1作为前列腺癌的一个风险因素。