Wilson R Douglas, Johnson Mark P
The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Semin Pediatr Surg. 2003 Aug;12(3):182-9. doi: 10.1016/s1055-8586(03)00027-1.
The authors reviewed the status of closed ultrasound-guided fetal therapy using a pigtail shunt to create vesicoamniotic or thoracoamniotic decompression of the fluid-filled space. This review includes published and textbook reports of in utero therapy for bladder obstruction, pleural effusion, and macrocystic adenomatoid malformation from 1985 through 2002. For fetuses affected by lower urinary tract obstruction, the key component is identifying those fetuses that have retained renal function and are most likely to benefit from in utero shunting. This good prognosis group has been shown to have improved survival rate and a lower incidence of renal failure. Complications of fetal loss are estimated at 5% owing to the shunt procedure, and the risk of shunt displacement varies from 30% to 50%. Hydrops secondary to primary PE has been shown to be associated with low fetal and neonatal survival at 21% to 23%. Treatment by thoracoamniotic shunting increases survival rate to 75%. The fetus with a macrocystic CCAM and secondary hydrops should be considered a candidate for thoracoamniotic shunt to decrease CCAM volume, reverse hydrops, and improve survival rate. Thoracoamniotic shunt and thoracocentesis pregnancy loss risks for pleural effusion (PE) and macrocystic adenomatoid malformation of the lung (CCAM) are 5% and 0.5% to 1.0%, respectively.
作者回顾了使用猪尾分流器进行闭合性超声引导下胎儿治疗的现状,以实现对充满液体腔隙的膀胱羊膜腔或胸腔羊膜腔减压。本综述涵盖了1985年至2002年期间关于膀胱梗阻、胸腔积液和肺大囊性腺瘤样畸形的宫内治疗的已发表报告和教科书内容。对于受下尿路梗阻影响的胎儿,关键在于识别那些保留肾功能且最有可能从宫内分流中获益的胎儿。已证实,这一预后良好的群体生存率提高,肾衰竭发生率降低。由于分流手术,胎儿丢失的并发症估计为5%,分流移位的风险在30%至50%之间。原发性胸腔积液继发的水肿已被证明与胎儿和新生儿低生存率相关,为21%至23%。通过胸腔羊膜腔分流治疗可将生存率提高至75%。患有肺大囊性腺瘤样畸形和继发性水肿的胎儿应被视为胸腔羊膜腔分流的候选对象,以减少肺大囊性腺瘤样畸形的体积、逆转水肿并提高生存率。胸腔积液(PE)和肺大囊性腺瘤样畸形(CCAM)的胸腔羊膜腔分流和胸腔穿刺术导致的妊娠丢失风险分别为5%和0.5%至1.0%。