体外受精和绒毛取样后三胎妊娠中的脐膨出-膀胱外翻-肛门闭锁-脊柱裂（OEIS）综合征
Omphalocele-exstrophy-imperforate anus-spinal defects (OEIS) in triplet pregnancy after IVF and CVS.
作者信息
Shanske Alan L, Pande Sumati, Aref Karim, Vega-Rich Carlos, Brion Luc, Reznik Sandra, Timor-Tritsch Ilan E
机构信息
Center for Congenital Disorders, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York 10467, USA.
出版信息
Birth Defects Res A Clin Mol Teratol. 2003 Jun;67(6):467-71. doi: 10.1002/bdra.10058.
BACKGROUND
Omphalocele-exstrophy-imperforate anus-spinal defects (OEIS) complex is a rare sporadic condition.
CASE
We identified an infant with major malformations resembling OEIS. He was the product of a 30-week triplet pregnancy conceived by in vitro fertilization (IVF) and evaluated by chorionic villi sampling (CVS). In this article, we review the possible pathogenetic mechanisms in this case, including IVF, multiple gestation, trauma to the uterus or uterine vessels following CVS, and placenta accreta.
CONCLUSIONS
We conclude that the cumulative effects of all or some of these factors may have resulted in uteroplacental insufficiency adequate to produce this phenotype. This case provides additional evidence for the uterine vascular pathogenesis of OEIS complex in humans.
背景
脐膨出-泄殖腔外翻-肛门闭锁-脊柱裂（OEIS）综合征是一种罕见的散发性疾病。
病例
我们发现一名患有类似OEIS严重畸形的婴儿。他是通过体外受精（IVF）受孕的30周三胞胎妊娠产物，并接受了绒毛取样（CVS）评估。在本文中，我们回顾了该病例可能的发病机制，包括IVF、多胎妊娠、CVS后子宫或子宫血管创伤以及胎盘植入。
结论
我们得出结论，所有这些因素或其中一些因素的累积效应可能导致子宫胎盘功能不全，足以产生这种表型。该病例为人类OEIS综合征的子宫血管发病机制提供了额外证据。
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