肺移植术后血中环孢素C0和C2浓度与巨细胞病毒感染
Blood cyclosporine C0 and C2 concentrations and cytomegalovirus infections following lung transplantation.
作者信息
Monforte V, Bullich S, Pou L, Bravo C, López R, Gavaldà J, Roman A
机构信息
Department of Pneumology, Hospital General Vall d'Hebron, Barcelona, Spain.
出版信息
Transplant Proc. 2003 Aug;35(5):1992-3. doi: 10.1016/s0041-1345(03)00689-4.
The aim of this study was to determine whether cyclosporine levels predose (C0) and at two hours postdose (C2) were higher among patients presenting with cytomegalovirus (CMV) infection or disease. Between days 40 and 365 posttransplantation serial C0 and C2 levels were measured in 15 lung transplant recipients. Nine developed 13 episodes of CMV infection or disease. Both C0 and C2 levels were higher during CMV infection or disease episodes. Eleven of the 13 CMV episodes (84%) displayed C0 >220 ng/mL and none had C0 <200 ng/mL. For C2, 11 of 13 CMV episodes (84%) showed C2 >1200 ng/mL and none had C2 <1000 ng/mL. Among determinations that did not coincide with a CMV episode, 7 of 21 (33%) showed C0 >220 and 9 of 21 (42%) showed C2 >1200, respectively (P<.05). In conclusion, cyclosporine blood levels are higher among patients presenting with CMV infection or disease.
本研究的目的是确定巨细胞病毒（CMV）感染或疾病患者的环孢素给药前水平（C0）和给药后两小时水平（C2）是否更高。在移植后40天至365天期间，对15名肺移植受者的C0和C2水平进行了连续测量。9名患者发生了13次CMV感染或疾病发作。在CMV感染或疾病发作期间，C0和C2水平均较高。13次CMV发作中的11次（84%）显示C0>220 ng/mL，无一例C0<200 ng/mL。对于C2，13次CMV发作中的11次（84%）显示C2>1200 ng/mL，无一例C2<1000 ng/mL。在与CMV发作不相符的测定中，21次中有7次（33%）显示C0>220，21次中有9次（42%）显示C2>1200（P<0.05）。总之，CMV感染或疾病患者的环孢素血药水平较高。
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