进行性轴索性多发性神经病和单克隆丙种球蛋白病中腓肠神经T细胞增加。

Increase of sural nerve T cells in progressive axonal polyneuropathy and monoclonal gammopathy.

作者信息

Eurelings M, van den Berg L H, Wokke J H J, Franssen H, Vrancken A F J E, Notermans N C

机构信息

Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands.

出版信息

Neurology. 2003 Sep 9;61(5):707-9. doi: 10.1212/01.wnl.0000078103.71192.40.

DOI:10.1212/01.wnl.0000078103.71192.40

PMID:12963771

Abstract

The authors investigated whether T cells have a role in the pathogenesis of axonal polyneuropathy and monoclonal gammopathy by comparing the presence of T cells in sural nerves of 23 patients with axonal polyneuropathy and monoclonal gammopathy (12 IgM, 11 IgG), of 15 patients with chronic idiopathic axonal polyneuropathy, and of 10 autopsy cases. Seven patients with an increased T-cell density had a progressive disease course, and four of these patients were treated with prednisone with a good response, suggesting that vasculitis plays a role in the pathogenesis.

摘要

作者通过比较23例伴有单克隆丙种球蛋白病的轴索性多发性神经病患者（12例IgM型，11例IgG型）、15例慢性特发性轴索性多发性神经病患者以及10例尸检病例的腓肠神经中T细胞的存在情况，研究了T细胞在轴索性多发性神经病和单克隆丙种球蛋白病发病机制中的作用。7例T细胞密度增加的患者病程呈进行性，其中4例患者接受泼尼松治疗后反应良好，提示血管炎在发病机制中起作用。