Co2(CO)6络合的炔丙基自由基的自发生成及立体选择性偶联

Spontaneous generation and stereoselective coupling of Co2(CO)6-complexed propargyl radicals.

作者信息

Melikyan Gagik G, Villena Ferdinand, Sepanian Steve, Pulido Michelle, Sarkissian Hagop, Florut Arthur

机构信息

Department of Chemistry, California State University-Northridge, Northridge, California 91330, USA.

出版信息

Org Lett. 2003 Sep 18;5(19):3395-7. doi: 10.1021/ol030074q.

DOI:10.1021/ol030074q

PMID:12967283

Abstract

[reaction: see text] The spontaneous generation and stereoselective coupling of Co(2)(CO)(6)-complexed propargyl radicals have been discovered. One- and two-step complementary methods (Method A: (1) HBF(4); (2) CH(2)Cl(2), 20 degrees C; Method B: Tf(2)O, CH(2)Cl(2), 20 degrees C) provided an easy access to synthetically useful d,l-3,4-diaryl-1,5-alkadiynes (de 74-98%).

摘要

[反应：见正文] 已发现Co(2)(CO)(6)络合的炔丙基自由基的自发生成和立体选择性偶联。一步法和两步法互补方法（方法A：(1) HBF(4)；(2) CH(2)Cl(2)，20℃；方法B：Tf(2)O，CH(2)Cl(2)，20℃）为合成有用的d，l-3，4-二芳基-1，5-二炔烃（对映体过量74-98%）提供了简便途径。