磷脂酰肌醇-3,5-二磷酸找到了一个伙伴。

PtdIns(3,5)P2 finds a partner.

作者信息

Hicke Linda

机构信息

Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA.

出版信息

Dev Cell. 2003 Sep;5(3):363-4. doi: 10.1016/s1534-5807(03)00271-5.

DOI:10.1016/s1534-5807(03)00271-5

PMID:12967555

Abstract

Phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P(2)) is required for the sorting of a subset of membrane proteins at the late endosome. Unlike other phosphoinositides, binding partners for PtdIns(3,5)P(2) and its mechanism of action have not been characterized. New work by in this issue of Developmental Cell describes the identification of a yeast epsin-like protein that binds PtdIns(3,5)P(2) and functions in the transport of proteins through late endosomes to the lysosome-like vacuole.

摘要

磷脂酰肌醇-3,5-二磷酸（PtdIns(3,5)P(2)）是晚期内体中一部分膜蛋白分选所必需的。与其他磷酸肌醇不同，PtdIns(3,5)P(2)的结合伴侣及其作用机制尚未明确。本期《发育细胞》中的一项新研究描述了一种酵母类epsin蛋白的鉴定，该蛋白可结合PtdIns(3,5)P(2)，并在蛋白质通过晚期内体运输到溶酶体样液泡的过程中发挥作用。