合成抗疟三氧杂环乙烷对四苯基卟啉锰（II）的烷基化作用
Alkylation of manganese(II) tetraphenylporphyrin by a synthetic antimalarial trioxane.
作者信息
Berrien Jean-François, Provot Olivier, Mayrargue Joëlle, Coquillay Michel, Cicéron Liliane, Gay Frédérick, Danis Martin, Robert Anne, Meunier Bernard
机构信息
UMR 8076 BioCIS, Faculté de Pharmacie, rue J.-B. Clément, F-92296 Châtenay-Malabry, France.
出版信息
Org Biomol Chem. 2003 Aug 21;1(16):2859-64. doi: 10.1039/b302835f.
DOI:10.1039/b302835f
PMID:12968336
Abstract
The synthesis and the antimalarial activity of a new kind of polycyclic 1,2,4-trioxanes are reported. The alkylation of the heme model MnIITPP by the biologically active (IC 50 = 320 nmol L-1) hemiperketal 2 is presented.
摘要
报道了一种新型多环1,2,4-三氧杂环己烷的合成及其抗疟活性。介绍了具有生物活性（IC50 = 320 nmol L-1）的半缩酮2对血红素模型MnIITPP的烷基化反应。
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