Mottram Patricia L
Austin Research Institute, Kronheimer Building, Austin and Repatriation Medical Centre, Melbourne, Australia.
Immunol Cell Biol. 2003 Oct;81(5):350-3. doi: 10.1046/j.1440-1711.2003.01184.x.
Historically, treatment of complex autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus has aimed to relieve symptoms, and in severe cases, use broad-spectrum immunosuppressive treatments in attempts to induce permanent remission. Recent research into the causes of chronic autoimmune inflammatory activation have not only explored the mechanism of action of known therapies, but also provided a number of new targets for therapy, by identifying the cells, cytokines and signalling pathways activated during autoimmune antibody mediated processes. This review briefly outlines progress in the understanding of the autoimmune nature of rheumatoid diseases and the expansion of treatment options, from broad to specific immunotherapies for these closely related diseases.
从历史上看，类风湿关节炎和系统性红斑狼疮等复杂自身免疫性疾病的治疗旨在缓解症状，在严重情况下，使用广谱免疫抑制疗法试图诱导永久缓解。最近对慢性自身免疫性炎症激活原因的研究不仅探索了已知疗法的作用机制，还通过识别自身免疫抗体介导过程中激活的细胞、细胞因子和信号通路，提供了许多新的治疗靶点。本综述简要概述了在理解类风湿疾病的自身免疫本质以及治疗选择的扩展方面所取得的进展，从针对这些密切相关疾病的广泛免疫疗法到特异性免疫疗法。
