Kosmala M, Oledzka K, Lewandowski K, Filczewski M, Miłobedzka J
Pharmaceutical Research Institute, Department of Pharmacology, Warszawa, Poland.
Pol J Pharmacol Pharm. 1992 Sep-Oct;44(5):437-42.
Oral dose of enalapril or captopril moderately reduced the blood pressure of the spontaneously hypertensive rats (SHR) but not those of normotensive rats. The single daily dose of captopril (30 mg/kg) produced antihypertensive response equivalent to enalapril (3 mg/kg). Chronic administration of these drugs for 2 weeks revealed that systolic blood pressure was reduced more by captopril than enalapril. We did not find differences in hypotensive activity between Enalapril IF and Renitec Merck as well as Captopril JZF Polfa and Capoten Squibb.
口服依那普利或卡托普利可适度降低自发性高血压大鼠（SHR）的血压，但对正常血压大鼠无效。卡托普利每日单次剂量（30毫克/千克）产生的降压反应与依那普利（3毫克/千克）相当。连续2周长期服用这些药物显示，卡托普利降低收缩压的效果比依那普利更显著。我们未发现依那普利注射剂与默克瑞泰克、卡托普利JZF波尔法与施贵宝开博通之间在降压活性上存在差异。
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