Géléoc Gwénaëlle S G, Holt Jeffrey R
Department of Neuroscience and Department of Otolaryngology, University of Virginia School of Medicine, Box 801392, Charlottesville, Virginia 22908, USA.
Nat Neurosci. 2003 Oct;6(10):1019-20. doi: 10.1038/nn1120. Epub 2003 Sep 14.
Sensory transduction in hair cells requires assembly of membrane-bound transduction channels, extracellular tip-links and intracellular adaptation motors with sufficient precision to confer nanometer displacement sensitivity. Here we present evidence based on FM1-43 fluorescence, scanning electron microscopy and RT-PCR that these three essential elements are acquired concurrently between embryonic day 16 and 17, several days after the appearance of hair bundles, and that their acquisition coincides with the onset of mechanotransduction.
毛细胞中的感觉转导需要膜结合转导通道、细胞外纤毛连接和细胞内适应马达精确组装,以赋予纳米级位移敏感性。在此,我们基于FM1-43荧光、扫描电子显微镜和逆转录聚合酶链反应提出证据,表明这三个基本元件在胚胎第16至17天同时获得,这是在毛束出现几天后,并且它们的获得与机械转导的开始相吻合。